Endocrine Abstracts

Introduction: Non-functioning pituitary adenomas (NFPA) are characterised by the expression of somatostatin receptors (SSTR), which is analysed using immunohistochemical investigations. The presence of SSTR forms the basis for the clinical use of somatostatin analogues (SSA) in the treatment of these tumours.Aim: The study was undertaken to provide immunohistochemical analysis of SSTR and to correlate it with tumoral response to SSA therapy in NFPA.<...

Introduction: Somatostatin analogues (SSAs) are used in the treatment of somatotropinomas. Actually, the use of these drugs in clinically non-functioning pituitary adenomas (NFPA) is raised. The aim of the study is to assess the effectiveness of SSA therapy in both groups.Materials and methods: 40 acromegalic patients and 22 patients with NFPA were treated with SSA for the total therapy duration up to 10 years. Hormonal profile, dynamics of tumour size c...